How common is Pediatric Surgery?

3.9 million pediatric surgeries are performed
each year in the U.S.1


  • ACL Repair
  • Scoliosis
  • Spinal Surgery Appendectomy
  • Hernia Repair
  • Oral Surgery (such as tonsillectomy and wisdom tooth removal)

Opioids, which are commonly prescribed to manage pain following these types of surgeries, often come with unwanted side effects including nausea, vomiting, constipation, and more.

Cap3 out of 10 kids who receive opioid prescriptions before their high school graduation are more likely to misuse opioids in the future.2

Pediatric Surgeryb

If your child is preparing to have surgery, ask about non-opioid options that can manage their pain while reducing – or in some cases eliminating – their need for opioids while providing an enhanced recovery experience.

There are effective non-opioid options available to manage pain that may help your child during recovery.

Exparel Logo

EXPAREL is the first and only FDA-approved long-lasting non-opioid pain management medication studied in ages six and above. The safety and effectiveness of EXPAREL in children has been demonstrated to provide3*

  • Effective pain management designed with children’s safety in mind
  • Reduction or elimination of the need for opioids
  • Long-lasting pain management for the critical first few days following surgery to help enhance recovery
  • *The PLAY study assessed the safety of EXPAREL in children 6 to <17 years old.
  • The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials.

Other Pages to Check out

Indication EXPAREL® (bupivacaine liposome injectable suspension) is indicated in patients 6 years of age and older for single-dose infiltration to produce postsurgical local analgesia, and in adults as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia. Safety and efficacy have not been established in other nerve blocks.

Important Safety Information

  • EXPAREL should not be used in obstetrical paracervical block anesthesia.
  • In studies in adults where EXPAREL was injected into a wound, the most common side effects were nausea, constipation, and vomiting.
  • In studies in adults where EXPAREL was injected near a nerve, the most common side effects were nausea, fever, and constipation.
  • In the study where EXPAREL was given to children, the most common side effects were nausea, vomiting, constipation, low blood pressure, low number of red blood cells, muscle twitching, blurred vision, itching, and rapid heartbeat.
  • EXPAREL can cause a temporary loss of feeling and/or loss of muscle movement. How much and how long the loss of feeling and/or muscle movement depends on where and how much of EXPAREL was injected and may last for up to 5 days.
  • EXPAREL is not recommended to be used in patients younger than 6 years old for injection into the wound, for patients younger than 18 years old for injection near a nerve, and/or in pregnant women.
  • Tell your health care provider if you or your child has liver disease, since this may affect how the active ingredient (bupivacaine) in EXPAREL is eliminated from the body.
  • EXPAREL should not be injected into the spine, joints, or veins.
  • The active ingredient in EXPAREL can affect the nervous system and the cardiovascular system; may cause an allergic reaction; may cause damage if injected into the joints; and can cause a rare blood disorder.

For full prescribing information, please visit or call 1-855-793-9727. You are encouraged to report negative side effects to the FDA. Visit or call 1-800-FDA-1088.



  • 1 Rabbitts JA, Groenewald CB. Epidemiology of Pediatric Surgery in the United States. Paediatr Anaesth. 2020 Oct;30(10):1083-1090. doi: 10.1111/pan.13993. Epub 2020 Aug 29. PMID: 32777147; PMCID: PMC7891905.
  • 2 Miech R, Johnston L, O’Malley PM, Keyes KM, Heard K. Prescription Opioids in Adolescence and Future Opioid Misuse. Pediatrics. 2015 Nov;136(5):e1169-77. doi: 10.1542/peds.2015-1364. PMID: 26504126; PMCID: PMC4834210.
  • 3 Tirotta CF, de Armendi AJ, Horn ND, et al. A multicenter study to evaluate the pharmacokinetics and safety of liposomal bupivacaine for postsurgical analgesia in pediatric patients aged 6 to less than 17 years (PLAY). J Clin Anesth. 2021;75:11053.